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illustration of targeting cancer cells

University Hospitals Seidman Cancer Center - At the Forefront of Cancer Research

At University Hospitals Seidman Cancer Center, we’re committed to advancing cancer care through innovative research that transforms treatment and improves patient outcomes. Our physician-scientists are driving discoveries in genomics, immunotherapy, gene editing and radiation therapy—developing more targeted, personalized approaches based on the molecular profile of each patient’s cancer.

Our groundbreaking research initiatives include the latest in antibody treatments to harness the body’s immune system and block cancer cell growth. For instance, new checkpoint inhibitors are being used to activate the immune system to identify and destroy cancer cells. Likewise, ongoing research is expanding the application of CAR T-Cell Therapy, a leading-edge technology that enables clinician scientists to modify a patient’s own immune system to locate and eradicate cancer cells.

Emerging Innovations in Immunotherapy, Gene Editing and Radiation Advancing Cancer Care

Additional research explores the use of bispecific antibodies to attack cancer cells by attracting immune cells, including T-cell and NK cells, to the tumor site to instigate cytotoxic activity. Future research will apply gene editing to address a person’s predisposition to certain cancers by removing specific genes. Continued studies and strides in radiation therapy are also rapidly advancing the realm of what is clinically possible to provide cancer patients with the most state-of-the-art care and effective treatments to extend their lifespan and enhance their quality of life. Adaptive radiotherapy, which allows for real-time adjustments to radiation therapy for improved clinical precision, and theranostics, or radiopharmaceutical therapy, which uses radioisotopes to combine diagnostic imaging and therapeutic treatment, are among the latest in radiation therapies to benefit cancer patient.

researcher in scrubs using pipette in the Wesley Center for Immunotherapy

At University Hospitals State-of-the-art Research Facilitates Accelerate Scientific Progress

Our clinician scientists employ the latest technologies and techniques to engage in the most state-of-the-art research, leveraging the strength and capacity of onsite facilities. A cornerstone of our innovation is the Wesley Center for Immunotherapy at UH Seidman Cancer Center, one of only a few centers in the country manufacturing CAR T-cells and NK cell therapies onsite, accelerating access to breakthrough treatments. This groundbreaking, state-of-the-art cellular therapy facility is at the forefront of cancer care as physician scientists generate CAR T, NK cell and other cell-based therapies onsite to bring new, life-extending immunotherapy treatments more quickly to patients. The Center is one of only a few nationwide to have successfully manufactured CAR T-cells for human use immunotherapy that uses the body’s own T-cells to fight cancer.

Science@UH Podcast: Cancer Research

Listen to physician scientists dive deep into research being done at UH Seidman Cancer Center.

Discovering New Forms of Prevention and Treatment Through Cancer Research

As a proud member of the Case Comprehensive Cancer Center, UH Seidman is committed to translating research into real-world therapies—giving patients access to clinical trials and investigational treatments not widely available elsewhere. Cancer research not only advances the state-of-the-art in cancer treatment, it also provides a source of hope and help to patients for whom other treatments have failed.

arial view of University Hospitals and Case Western Reserve University School of Medicine campus